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Case Report
Urinary retention by mirtazapine: A case report
Madhav Gajananrao Raje
Consultant Psychiatrist, India

Article ID: 100040CRINTMR2017

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Dr. Madhav Raje
Consultant Psychiatrist

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How to cite this article
Raje MG. Urinary retention by mirtazapine: A case report. Case Rep Int 2017;6:35–38.

Introduction: Mirtazapine is considered to be safest and versatile antidepressant. However, sedation is known to be dose dependent side effect. 7.5 mg/day mirtazapine induces more sedation than 15 mg/day mirtazapine. There is no other side effect of mirtazapine which is reported to be dose dependent.
Case Report: Here is a case, where dose dependent urinary retention is detected. A 38-year-old married female reported with array of recurring symptoms like dysphoria, insomnia, loss of appetite, burning all over, uneasiness, increased frequency of micturation and stool, irritability, frustration, weeping often. She was symptomatic since last five to six years, despite regular psychiatric treatment. Her earlier psychiatrist had expressed inability to treat recurrence and intensity of her symptoms. She was kept on mirtazapine 7.5 mg per day to begin with. She responded favorably. To gain more relief dose of mirtazapine was increased to 15 mg/day. Within one to two days she complained of inability to pass urine. Her complaint was specific that she was not able to empty her bladder completely. After completing the act of micturation she used to experience much discomfort in pelvic region. Further investigations revealed significant urinary retention. Lowering of dose brought her relief immediately.
Conclusion: Mirtazapine with dose of 7.5 mg per day effectively could treat recurring symptoms of a female patient. But increase in dose up to 15 mg/day caused significant side effect of urinary retention against the conventional belief of rise in dose of mirtazapine would increase the relief.

Keywords: Dose dependant side effect, Mirtazapine, Rare adverse effect, Urinary retention

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Author Contributions
Madhav Gajananrao Raje – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
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The corresponding author is the guarantor of submission.
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Conflict of interest
Authors declare no conflict of interest.
© 2017 Madhav Gajananrao Raje. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.


Madhav Gajananrao Raje is consultant psychiatrist and psychotherapist at Nagpur, India. Qualifications: MD (FMT), DFM (Famiily Medicine), DPM (Psychiatry), MSc CFT (Counseling and Family Therapy), BA Psychology, MA Philosophy, DPC. He has published 10 research papers in national & international Journals. He has authored a book individually and authored two chapters in a reference multi-authored book. His research interests include Adult ADHD, OCD, psychotropic medicine, multi centered psychiatric research projects. He intends to pursue academic collaboration with other researchers in the field of psychology/psychiatry.

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