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Human embryonic stem cell for the treatment of multiple sclerosis: A case report
Geeta Shroff
MBBS, Founder and Director, H8, Green Park Extension, New Delhi, India. Email ID:geetashroff@hotmail.com

Article ID: 100015CRINTGS2015
doi:10.5348/crint-2015-15-CR-10

Address correspondence to:
Geeta Shroff
H8, Green Park Extension
New Delhi 110016
India
Phone: +91 11 26180039

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How to cite this article:
Shroff G. Human embryonic stem cell for the treatment of multiple sclerosis: A case report. Case Rep Int 2015;4:38–42.


Abstract
Introduction: Multiple sclerosis (MS) is a chronic demyelinating disease with inflammatory neurodegeneration. It is caused by the genesis of autoimmune response to self-antigens in a genetically susceptible individual. Currently, no remedy is available for treatment of MS. However, corticosteroids and selective immunomodulators are used. Human embryonic stem cells (hESC) have been investigated in animal models which showed the potency to mitigate the signs and symptoms of MS. We present a case of patient with MS treated with hESC therapy.
Case Report: A 34-year-old female with MS was referred to our facility. On presentation, the patient was unable to walk properly due to stiffness and paralysis in lower limbs and had significant weight loss in the last two years. The hESC therapy consisted of treatment phases separated by gap phases. After the hESC therapy, there was a remarkable improvement in the muscle bulk, tone and power of the patient. The patient experienced an increased energy level and power of upper limbs. She gained weight during the treatment, but there was no change in her walking status.
Conclusion: We observed a significant improvement in the symptoms of MS with the hESC treatment. There was no adverse event observed during the treatment.

Keywords: Autoimmune, Human embryonic stem cell, Inflammatory neurodegeneration, Multiple sclerosis


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Author Contributions
Geeta Shroff – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2015 Geeta Shroff. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



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